Official websites use. Share sensitive information only on official, secure websites. Cite this article as: Yilmaz H. North Clin Istanb ;9 1 :8— Failure to comply with medications causes disease activation, loss of response to treatment, and increased hospitalization rates. Drug non-adherence worsens the course of the disease, leading to fistula, stricture, and surgical interventions. This study was conducted as prospective cohort study at the tertiary health care institution inflammatory bowel disease outpatient clinic within 1 year. Medication adherence was assessed by calculating the medication possession ratio using the amount of medication purchased from the pharmacy. A total of patients were included in the study. It was observed that It was determined that the patients who did not adhere to the medication were significantly younger 41±12 vs. The duration of the disease is shorter in patients who did not comply with the drugs 4. Adherence with medication is lower in patients with higher education levels Young and highly educated patients with shorter disease duration should be targeted for measures to Best Way To Have Sex In A Car the rates of medication adherence. It is estimated to affect 1. Its incidence was reported 4. Roughly half of the patients develop intestinal complications within 10 years after diagnosis and require surgical intervention within 20 years [ 5 ]. Factors negatively associated with short- and long-term treatment include but are not limited to access to a gastroenterologist, the traveling distance to hospital, lead time to effective treatment, genetic factors, dysbiosis, side effects of medications, and not adhering to medication. Medical treatment is the mainstay of symptomatic relief, maintenance of remission, and prevention of complications [ 6 ]. Not adhering to taking medication was previously found to be associated with flares, relapses, loss of response to medication, decrease in the QoL, morbidity, and mortality. When inflammatory bowel disease IBD patients experienced flare the costs increased 2—3-fold on an outpatient basis. In case of hospitalization due to flares costs increased up to fold [ 9 ]. Non-adherence to medication is complex and driven by many factors. The factors include young age, the male sex, marital status, employment status, depression, periods of remission, multiple drugs, multiple doses, routes of drug administrations, adverse effects, and the relationships of patients and doctors. These factors were defined in the very heterogeneous cohorts and populations with different cultural heritage. Thus, outcomes need to be confirmed in the Turkish population and it is necessary to define new factors that could be generalizable. The factors that may affect non-adherence to medication for future targeted interventions for better outcomes of the disease were investigated. Those who did not give informed consent, patients with active psychiatric disorders on the sedative and hypnotic drugs, alcohol abusers, and patients with history of sleep disorder were also excluded from the study. Patient demographic information and data that may affect adherence to treatment were the smoking status, disease activity, delay time of diagnosis, level of education, and medications. Disease activity was calculated using the Harvey Bradshaw Index [ 10 ]. Scores below 4 were considered as a disease in remission and more than 5 were active diseases. Uncomplicated patients and data on patients with complications such as fistula, stricture, intra-abdominal abscess, and perianal disease were extracted from the hospital electronic record system. Patients with primary, secondary, and high school education were defined as low educated, and patients with college, university, and doctoral education degrees were defined as highly educated. In other words, it defines the delay time of diagnosis. The median disease duration is 4. Those with higher education status are significantly non-adherent to medications. Adherence to taking medication was calculated with the medication possession ratio MPR. The days and amounts of medication dispensed from pharmacies were retrospectively extracted for the 12 months. The MPR was calculated by dividing the number of drugs purchased from the pharmacy by the number of days during the period of observation.
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